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ANTIVIRALS
Acyclovir(
Zovirax® )
Antiviral
- Acute Treatment of Herpes Zoster
800 mg every 4 hours orally, 5 times daily for 7 to 10 days.
- Initial Genital Herpes Simplex:
200 mg every 4 hours, 5
times daily for 10 days.
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Chronic Suppressive Therapy for Recurrent Disease
400 mg 2 times daily for up
to 12 months, followed by re-evaluation.
Alternative regimens have included
doses ranging from 200 mg 3 times daily to 200 mg 5 times daily.
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Intermittent Therapy
200 mg every 4 hours, 5 times daily for 5 days. Therapy
should be initiated at the earliest sign or symptom (prodrome) of recurrence.
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Severe Disease (complicated disease -e.g. disseminated infection,
pneumonitis, hepatitis, meningitis or encephalitis)
5–10 mg/kg body weight IV every 8 hours for 2–7 days or until clinical
improvement is observed, followed by oral antiviral therapy to complete at least
10 days of total therapy [1].
- Chickenpox (Varicella-zoster)
Adults and Children over 40 kg: 800 mg 4 times daily for 5 days.
Adjust dose in patients with acute or chronic renal impairment(200, 400, 800 mg tablets; 200 mg /5 mL suspension -Bottle of 1 pint -473 mL)
Pregnancy
Category B
SEE ALSO Drugsafetysite.com/acyclovir
Famciclovir(Famvir®)
Antiviral
-
Herpes Zoster
500 mg every 8 hours for 7 days. No data are available
on efficacy of treatment started greater than 72 hours after rash onset.
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Herpes Simplex Infections
-
Recurrent genital herpes:
125 mg twice daily for 5
days. The efficacy of Famvir (famciclovir)
has not been established when treatment is initiated more than 6 hours after
onset of symptoms or lesions.
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Suppression of recurrent genital herpes:
250 mg twice
daily for up to 1 year. The safety and efficacy of Famvir therapy beyond 1 year
of treatment have not been established.
-
HIV-Infected Patients
Recurrent orolabial or genital herpes simplex infection:
500 mg twice daily for 7 days.
In patients with reduced renal function, dosage reduction is recommended
(125 , 250, 500 mg tablets)
Pregnancy
Category B
SEE ALSO Drugsafetysite.com/famciclovir
Valacyclovir
(Valtrex®)
Antiviral
- Acute Treatment of Herpes Zoster:
1
gram 3 times daily for 7 days. Therapy should be initiated at the earliest
sign or symptom of herpes zoster .
- Genital Herpes Initial Episode:
1 gram twice daily for 10 days. Therapy is most effective when administered within 48 hours of the onset of signs and symptoms.
-
Recurrent Genital Herpes Episodes:
500 mg twice daily for 3 days.
There are no data on the effectiveness of treatment with VALTREX when initiated more than 24 hours after the onset of signs or symptoms.
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Chronic Suppressive Therapy:
1 gram once daily in patients with normal immune function. In patients with a history of 9 or fewer recurrences per year, an alternative dose is 500 mg once daily. The safety and efficacy of therapy with VALTREX beyond 1 year have not been established.
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In HIV-infected patients with CD4 cell count ³100 cells/mm3
500 mg twice daily. The safety and efficacy of therapy with VALTREX beyond 6 months in patients with HIV infection have not been established.
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Reduction of Transmission in patients with a history of 9
or fewer recurrences per year:
500 mg once daily for the source partner. The efficacy of reducing transmission beyond 8 months in discordant couples has not been established.
- Cold Sores (Herpes Labialis):
2 grams twice daily for 1 day taken 12 hours
apart. Therapy should be initiated at the earliest symptom of a cold sore.
Adjust dose in patients with acute or chronic renal impairment
(500 mg, 1 gram caplets)
Pregnancy
Category B
SEE ALSO Drugsafetysite.com/valacyclovir REFERENCES;
1.
CDC Sexually Transmitted Diseases Treatment
Guidelines , 2006
MMWR August 4, 2006/ 55 (RR-11) |
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