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Initial Treatment of Anaphylactic Reactions [1] Initial
treatment of anaphylactic reaction (hives, flushing, wheezing,
shortness of breath, chest pain, tachycardia hypotension, etc) :
Stop infusion or medication and give:
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Epinephrine 0.3 mg (0.3 ml of 1:1000)subcutaneous/IM . Repeat x 1 after
15 minutes for persistent symptoms.
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Diphenhydramine 50 mg IV x 1 dose
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Ranitidine 1 mg per kg IV
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Treat hypotension with large volume of isotonic
crystalloid IV fluid (bolus).
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Hydrocortisone, 5 mg per kg, or approximately 250 mg IV
REFERENCES:
1. Tang AW. A
Practical Guide to Anaphylaxis. Am Fam Physician. 2003
1;68(7):1325-32. Review. Erratum in: Am Fam Physician. 2004 Mar
1;69(5):1049. PMID: 14567487
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