Vaccine, Typhoid
CATEGORY: C
Killed bacteria vaccine.

1st trimester exposure to the oral vaccine in 18 pregnancies resulted in two miscarriages (2.7 expected) and 16 normal infants. However, the sample size is too small to draw firm conclusions [1]. Typhoid vaccine may be indicated in pregnancy when susceptibility and exposure to typhoid are highly probable such as may occur with travel to areas where the disease is endemic or epidemic [2]. The oral vaccine is preferred [3].

BREAST FEEDING: Compatible [4,5].

SEARCH LITERATURE

1. Mazzone T, Celestini E, Fabi R, Pagano M, Serafini MA, Verdecchia P, Mastroiacovo P. Oral typhoid vaccine and pregnancy. Reprod Toxicol 8:278-9, 1994. MEDLINE
2. Immunization during pregnancy. ACOG technical bulletin number 160--October 1991. Int J Gynaecol Obstet. 1993 Jan;40(1):69-79. MEDLINE
3. ACOG Committee Opinion. Immunization during pregnancy.Obstet Gynecol. 2003 ;101:207-12.MEDLINE
4. Centers for Disease Control & Prevention. General Recommendations on Immunization: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR 43 (No. RR-1): 20-21, 1994.
5.Breastfeeding and Maternal Medication. Recommendations for Drugs in the Eleventh WHO Model list of Essential Drugs. pp 23-24 World Health Organization, 2002. 20 Avenue Appia ,1211 Geneva ,Switzerland
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