Antidepressant. Molecular weight:408.33.
In a studies performed
on rats and rabbits no teratogenic effects were found at doses of up to 210
and 75 mg per kg respectively .
A surveillance study of Michigan Medicaid recipients
reported that data on 100 newborns exposed to trazodone during the first trimester did not support an
association between trazodone and major malformations, specifically hypospadias, cardiovascular
defects, limb reduction defects, oral clefts, polydactyly, and spina
Einarson A, et al
found no increased rate in major malformations in 58
pregnancies after first
trimester exposure to trazodone .
BREAST FEEDING: The excretion of breast milk was studied in
six lactating women following the oral administration of a single trazodone
tablet (50 mg). The milk/plasma ratio of trazodone was 0.14 .
The American Academy of Pediatrics has classified trazodone as a
Which the Effect on Nursing Infants Is Unknown but May Be of Concern" 
1. Briggs GG,Freeman RK, Yaffe SJ, Drugs in Pregnancy and Lactation 6th edition,Baltimore, MD:
Williams & Wilkins,2002
2. Barcellona PS. Investigations on the possible teratogenic effects of
trazodone in rats and rabbits. Boll Chim Farm. 1970;109:323-32.
Einarson A, et al. A multicentre prospective controlled study to determine
the safety of trazodone and nefazodone use during pregnancy.Can J Psychiatry. 2003;48:106-10.MEDLINE
4. Verbeeck RK et al.Excretion of trazodone in breast milk.Br J Clin Pharmacol. 1986;22:367-70.MEDLINE
Transfer of drugs and other chemicals into human milk. Pediatrics. 2001
Last Update: 1/7/2004