in Pregnancy and Breastfeeding
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Drugs in Pregnancy
Simethicone (Gas-X, Mylicon, Phazyme)
Defoaming agent used to relieve flatulence. Mixture of
dimethyl polysiloxanes and silica gel. Molecular weight between 14,000 and
A study in volunteers measuring silicon in the blood (as the surrogate
marker for simethicone)
noted that blood and urine levels of silicone were similar at baseline and
after receiving a
simethicone-coated cellulose suspension (SonoRx® )or vehicle control.
This suggests minimal systemic absorption of simethicone .
1. SonoRx® product label, 1998.
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