Simethicone in Pregnancy and Breastfeeding
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Simethicone (Gas-X, Mylicon, Phazyme)
Defoaming agent used to relieve flatulence. Mixture of dimethyl polysiloxanes and silica gel. Molecular weight between 14,000 and 21,000

A study in volunteers measuring silicon in the blood (as the surrogate marker for simethicone) noted that blood and urine levels of silicone were similar at baseline and after receiving a simethicone-coated cellulose suspension (SonoRx® )or vehicle control. This suggests minimal systemic absorption of simethicone [1].


1. SonoRx® product label, 1998.

Created: 1/17/2004
Updated: 1/17/2004

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