Hydrocodone  in Pregnancy and Breastfeeding
      
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Hydrocodone bitartrate  
Opioid analgesic, Antitussive.  Molecular weight: 494.5
CATEGORY:C
CATEGORY: D if used for prolonged periods

A surveillance study of Michigan Medicaid recipients reported a greater than expected number of birth defects in 332 newborns after exposure to hydrocodone during the first trimester [1]. A preliminary report by Schick B et al. found no pattern of major malformations among 40 infants exposed during the first trimester to hydrocodone during first trimester [2]. 

Infants born to mothers who have been taking opioids regularly prior to delivery may be physically dependent and experience withdrawal signs during the neonatal period.

BREAST FEEDING: There is not enough published information to comment on the safety of hydrocodone during breast feeding. Consider using other agents.

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1. Briggs GG,Freeman RK, Yaffe SJ, Drugs in Pregnancy and Lactation 6th edition,Baltimore, MD: Williams & Wilkins,2002 p 661

2. Schick B, et al. Preliminary analysis of first trimester exposure to oxycodone and hydrocodone.[ Abstract] Reprod Toxicol. 1996;10:162.


 

Created: 11/17/2000
Updated: 11/30/2002
Updated: 1/10/2005

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