in Pregnancy and Breastfeeding
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Drugs in Pregnancy
A surveillance study of Michigan Medicaid recipients reported a greater than
expected number of birth defects in 332 newborns
after exposure to hydrocodone during the first trimester . A preliminary report by Schick B et al. found no
pattern of major malformations among 40 infants exposed during the
first trimester to hydrocodone during first trimester .
Opioid analgesic, Antitussive. Molecular weight: 494.5
CATEGORY: D if used for prolonged periods
Infants born to mothers who have been taking opioids regularly prior to
delivery may be physically dependent and experience withdrawal signs during the
BREAST FEEDING: There is not enough published information to comment
on the safety of hydrocodone during breast feeding. Consider using other agents.
1. Briggs GG,Freeman RK, Yaffe SJ, Drugs in Pregnancy and Lactation 6th edition,Baltimore, MD:
Williams & Wilkins,2002
2. Schick B, et al. Preliminary analysis of
first trimester exposure to oxycodone and hydrocodone.[ Abstract] Reprod Toxicol.
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