Chlorpheniramine (Chlor-Trimeton ®,Efidac ®, Teldrin ®)
Anihistamine. Molecular weight: 274.8
Results of The Collaborative Perinatal Project found no increase in the
incidence of major malformations among 1070 pregnancies exposed during the first four lunar months to chlorpheniramine
Aselton P, et. al. also found no increase in the incidence of major
malformations among 175
exposed during the first trimester to
Briggs et. al. reported that data from a surveillance study of Michigan
did not support an
association between chlorpheniramine
and major malformations in
61 newborns who had been exposed to chlorpheniramine
during the first trimester .
A prospective controlled trial of 68 pregnancies that had been exposed to chlorpheniramine
at any time during pregnancy found no increase in the incidence of major
malformations. One child was born with congenital hip dysplasia .
The American College of Obstetricians and Gynecologists (ACOG) and The
American College of Allergy, Asthma and Immunology (ACAAI) recommended
chlorpheniramine and tripelennamine as the antihistamines of choice for use
during pregnancy .
1. Briggs GG,Freeman RK, Yaffe SJ, Drugs in Pregnancy and Lactation 6th edition,Baltimore, MD:
Williams & Wilkins,2002
2. Heinonen OP, et al: Birth Defects and Drugs in Pregnancy. Publishing
Sciences Group Inc., Littleton, MA, 1977.p 323-34.
3. Aselton P, et al.First-trimester drug use and congenital disorders. Obstet Gynecol. 1985; 65: 451-5.MEDLINE
4. Diav-Citrin O, et al.
Pregnancy outcome after gestational exposure to loratadine or
antihistamines: a prospective controlled cohort study.J Allergy Clin Immunol. 2003; 111: 1239-43.MEDLINE
5. The use of newer asthma and
allergy medications during pregnancy. Position Statement. The American
College of Obstetricians and Gynecologists (ACOG) and The American College
of Allergy, Asthma and Immunology (ACAAI). Ann Allergy Asthma Immunol.