Cholrpheniramine in Pregnancy and Breastfeeding
      
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Chlorpheniramine (Chlor-Trimeton ,Efidac , Teldrin )
Anihistamine. Molecular weight: 274.8
CATEGORY:B [1]

Results of The Collaborative Perinatal Project found no increase in the incidence of major malformations among 1070 pregnancies exposed during the first four lunar months to chlorpheniramine [2].

Aselton P, et. al. also found no increase in the incidence of major malformations among 175 pregnancies exposed during the first trimester to chlorpheniramine [3].

Briggs et. al. reported that data from a surveillance study of Michigan Medicaid recipients did not support an association between chlorpheniramine and major malformations in 61 newborns who had been exposed to chlorpheniramine during the first trimester [1].

A prospective controlled trial of 68 pregnancies that had been exposed to chlorpheniramine at any time during pregnancy found no increase in the incidence of major malformations. One child was born with congenital hip dysplasia [4].

The American College of Obstetricians and Gynecologists (ACOG) and The American College of Allergy, Asthma and Immunology (ACAAI) recommended chlorpheniramine and tripelennamine as the antihistamines of choice for use during pregnancy [5].


SEARCH LITERATURE

1. Briggs GG,Freeman RK, Yaffe SJ, Drugs in Pregnancy and Lactation 6th edition,Baltimore, MD: Williams & Wilkins,2002 p 246-7
2. Heinonen OP, et al: Birth Defects and Drugs in Pregnancy. Publishing Sciences Group Inc., Littleton, MA, 1977.p 323-34.
3. Aselton P, et al.First-trimester drug use and congenital disorders. Obstet Gynecol. 1985; 65: 451-5.MEDLINE
4. Diav-Citrin O, et al. Pregnancy outcome after gestational exposure to loratadine or antihistamines: a prospective controlled cohort study.J Allergy Clin Immunol. 2003; 111: 1239-43.MEDLINE
5. The use of newer asthma and allergy medications during pregnancy. Position Statement. The American College of Obstetricians and Gynecologists (ACOG) and The American College of Allergy, Asthma and Immunology (ACAAI). Ann Allergy Asthma Immunol. 2000;84:475-480. MEDLINE

Created: 11/17/2000
Updated: 11/30/2002
Updated: 1/17/2004

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