Is doxylamine succinate (Unisom) safe during pregnancy?
Doxylamine succinate is as an antihistamine marketed as a sleep aid under the
trade name Unisom
A combination of doxylamine succinate and pyridoxine
hydrochloride is marketed as a treatment for nausea and vomiting of pregnancy under the
Diclegis (similar to the drug Diclectin) . Diclegis is labeled as Food and
Drug Administration (FDA) Category A by the manufacturer. "Adequate, well-controlled studies in pregnant women have not shown an increased
risk of fetal abnormalities to the fetus in any trimester of pregnancy."
The editors of Drugs in Pregnancy and
Lactation. A Reference Guide to Fetal and Neonatal Risk consider doxylamine compatible for use in pregnancy (embryo-fetal risk is very low
or nonexistent )
Consult with your health care provider before starting
or stopping ANY medication during pregnancy.