Home> Common Questions > Is doxylamine succinate (Unisom) safe during pregnancy?
Is doxylamine succinate (Unisom) safe during pregnancy?

Doxylamine succinate is as an antihistamine  marketed as a sleep aid under the trade name Unisom SleepTabs 

A combination of doxylamine succinate and pyridoxine hydrochloride is marketed as a treatment for nausea and vomiting of pregnancy under the trade name Diclegis (similar to the drug Diclectin) . Diclegis is labeled as Food and Drug Administration (FDA) Category A by the manufacturer. "Adequate, well-controlled studies in pregnant women have not shown an increased risk of fetal abnormalities to the fetus in any trimester of pregnancy."

The editors of Drugs in Pregnancy and Lactation.  A Reference Guide to Fetal and Neonatal Risk consider doxylamine compatible for use  in pregnancy (embryo-fetal risk is very low or nonexistent )

Consult with your health care provider  before starting or stopping  ANY medication during pregnancy.


1. http://www.unisom.com/sleeptabs.html
2Diclegis (doxylamine succinate and pyridoxine hydrochloride)
3.Briggs GG,Freeman RK, Yaffe SJ, Drugs in Pregnancy and Lactation 9th edition,Baltimore, MD: Williams & Wilkins,2011 p. 452-453

Reviewed by Mark Curran, M.D., FACOG


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